www.午夜视频_亚洲人在线播放_看一级黄色大片_免费高清av_国产成人精品国内自产拍免费看_日韩av一区二区三区在线观看

加入收藏 | 設為首頁 | 聯系我們

產品搜索

聯系我們

聯系人：蔣經理
電話：4008750250
號碼：
手機：18066071954
地址：南京市棲霞區緯地路9號
Email： zhangxiangwen@cobioer.com

產品展示 / PRODUCTS
藥靶細胞株 > kinase激酶細胞株 > CBP73194ETV6-NTRK3/BaF3

ETV6-NTRK3/BaF3
名稱 ETV6-NTRK3/BaF3
型號 CBP73194
報價
特點 ETV6-NTRK3/BaF3,母細胞：BaF3，凍存條件：90% FBS+10% DMSO
  • 詳細內容


CBP73194

I. Introduction

Cell Line Name：

ETV6-NTRK3/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10% FBS+1 ug/ml puromycin

Mycoplasma Status:

Negative


II.Background
ETV6-NTRK3 gene fusion is the translocation of genetic material between the ETV6 gene located on the short arm (designated p) of chromosome 12 at position p13.2 (i.e. 12p13.2) and the NTRK3 gene located on the long arm (designated q) of chromosome 15 at position q25.3 (i.e. 15q25.3) to create the (12;15)(p13;q25) fusion gene, ETV6-NTRK3. This new gene consists of the 5' end of ETV6 fused to the 3' end of NTRK3. ETV6-NTRK3 therefore codes for an chimeric oncoprotein consisting of the helix-loop-helix (HLH) protein dimerization domain of the ETV6 protein fused to the tyrosine kinase (i.e. PTK) domain of the NTRK3 protein. The ETV6 gene codes for the transcription factor protein, ETV6, which suppresses the expression of, and thereby regulates, various genes that in mice are required for normal hematopoiesis as well as the development and maintenance of the vascular network. NTRK3 codes for Tropomyosin receptor kinase C a NT-3 growth factor receptor cell surface protein that when bound to its growth factor ligand, neurotrophin-3, becomes an active tyrosine kinase that phosphorylates tyrosine residues on, and thereby stimulates, signaling proteins that promote the growth, survival, and proliferation of their parent cells. The tyrosine kinase of the ETV6-NTRK3 fusion protein is dysfunctional in that it is continuously active in phophorylating tyrosine residues on, and thereby continuously stimulating, proteins that promote the growth, survival, and proliferation of their parent cells. In consequence, these cells take on malignant characteristics and are on the pathway of becoming cancerous. Indeed, the ETV6-NTRK3 fusion gene appears to be a critical driver of several types of cancers. It was originally identified in congenital fibrosarcoma and subsequently found in secretory breast cancer (also termed juvenile breast cancer), Mammary analogue secretory carcinoma of salivary glands (also termed MASC or MASCSG), congenital fibrosarcoma, congenital mesoblastic nephroma, rare cases of acute myelogenous leukemia, ALK-negative Inflammatory myofibroblastic tumour, and radiation-induced papillary thyroid carcinoma.

III. Representative Data

1. WB of  ETV6-NTRK3/BaF3 expression

CBP73194 WB.jpg

2. Anti-proliferation assay

CBP73194 fig.png

Figure 2. Anti-proliferation assay of two reference compounds on the ETV6-NTRK3/BaF3 Stable Cell Line



如果你對CBP73194ETV6-NTRK3/BaF3感興趣，想了解更詳細的產品信息，填寫下表直接與廠家聯系：


留言框

  • 產品：

  • 您的單位：

  • 您的姓名：

  • 聯系電話：

  • 常用郵箱：

  • 省份：

  • 詳細地址：

  • 補充說明：

  • 驗證碼：

    請輸入計算結果（填寫阿拉伯數字），如：三加四=7

化工儀器網

推薦收藏該企業網站
主站蜘蛛池模板： 99热这里有精品 | 国产欧美精品区一区二区三区 | av免费网址 | 免费视频一区 | 91av在线免费观看 | 久久国产成人 | 精品一区二区三区在线观看国产 | 久久精品 | 超碰激情 | 性色av网站 | a级片www| 日韩精品亚洲专区在线观看 | 欧美精品一区二区三区在线 | 亚州av | 亚洲欧洲成人av每日更新 | 久久伊人操 | 久久久精品视频一区二区三区 | 亚州精品成人 | 成人一级黄色毛片 | 天天操夜夜骑 | 成年人在线观看视频 | 男女羞羞视频免费 | 精品久久久久久亚洲精品 | 欧美高清视频 | 久久免费视频在线 | 精彩视频一区二区三区 | 精品国产免费一区二区三区演员表 | 精品国产一区二区三区成人影院 | 国产精品综合一区二区 | 日本在线视频一区二区 | 亚洲一区日韩 | 欧美一区二区三区在线观看 | 国产黄色av电影 | 久久精品久久久久久 | 欧美激情精品久久久久 | 求个av网址 | 国产日韩久久 | 日本中文字幕一区 | 天堂在线www | 在线免费看黄 | 在线精品一区二区 |