www.午夜视频_亚洲人在线播放_看一级黄色大片_免费高清av_国产成人精品国内自产拍免费看_日韩av一区二区三区在线观看

加入收藏 | 設(shè)為首頁(yè) | 聯(lián)系我們

產(chǎn)品搜索

產(chǎn)品分類

聯(lián)系我們

聯(lián)系人：蔣經(jīng)理
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com

產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > kinase激酶細(xì)胞株 > CBP73186EML4-ALK V3b/BaF3

EML4-ALK V3b/BaF3
名稱 EML4-ALK V3b/BaF3
型號(hào) CBP73186
報(bào)價(jià)
特點(diǎn) EML4-ALK V3b/BaF3,母細(xì)胞：BaF3，凍存條件：90% FBS+10% DMSO
  • 詳細(xì)內(nèi)容


CBP73186
I. Introduction

Cell Line Name：

EML4-ALK V3b/BaF3

Host Cell:

Ba/F3

Stability:16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10% FBS+2ug/ml puromycin

Mycoplasma Status:

Negative


II.Background

Approximately 3–7% of lung tumors harbor ALK fusions (Koivunen et al. 2008; Kwak et al. 2010; Shinmura et al. 2008; Soda et al. 2007; Takeuchi et al. 2008; Wong et al. 2009). ALK fusions are more commonly found in light smokers (< 10 pack years) and/or never-smokers (Inamura et al. 2009; Koivunen et al. 2008; Kwak et al. 2010; Soda et al. 2007; Wong et al. 2009). ALK fusions are also associated with younger age (Inamura et al. 2009; Kwak et al. 2010; Wong et al. 2009) and adenocarcinomas with acinar histology (Inamura et al. 2009; Wong et al. 2009) or signet-ring cells (Kwak et al. 2010). Clinically, the presence of EML4-ALK fusions is associated with EGFR tyrosine kinase inhibitor (TKI) resistance (Shaw et al. 2009).

Multiple different ALK rearrangements have been described in NSCLC. The majority of these ALK fusion variants are comprised of portions of the echinoderm microtubule-associated protein-like 4 (EML4) gene with the ALK gene. At least nine different EML4-ALK fusion variants have been identified in NSCLC (Figure 1; Choi et al. 2008; Horn and Pao 2009; Koivunen et al. 2008; Soda et al. 2007; Takeuchi et al. 2008; Takeuchi et al. 2009; Wong et al. 2009). In addition, non-EML4 fusion partners have also been identified, including KIF5B-ALK (Takeuchi et al. 2009) and TFG-ALK (Rikova et al. 2007). Clinically, the presence of an ALK rearrangement is detected by fluorescence in situ hybridization (FISH) with an ALK break apart probe. FISH testing is not able to discern which particular ALK fusion is found in a clinical sample.


III. Representative Data

1. WB of EML4-ALK V3b/BaF3 expression

CBP73186 WB.jpg

Figure 1. WB of ALK expression

2. Anti-proliferation assay


Figure 2. Anti-proliferation assay of three reference compounds on the EML4-ALK V3b/BaF3 Stable Cell Line




如果你對(duì)CBP73186EML4-ALK V3b/BaF3感興趣，想了解更詳細(xì)的產(chǎn)品信息，填寫下表直接與廠家聯(lián)系：


留言框

  • 產(chǎn)品：

  • 您的單位：

  • 您的姓名：

  • 聯(lián)系電話：

  • 常用郵箱：

  • 省份：

  • 詳細(xì)地址：

  • 補(bǔ)充說明：

  • 驗(yàn)證碼：

    請(qǐng)輸入計(jì)算結(jié)果（填寫阿拉伯?dāng)?shù)字），如：三加四=7

化工儀器網(wǎng)

推薦收藏該企業(yè)網(wǎng)站
主站蜘蛛池模板： 久久久91精品国产一区二区三区 | 成人精品一区二区三区中文字幕 | av在线免费观看网址 | 狠狠色综合欧美激情 | 久久精品色欧美aⅴ一区二区 | 午夜精品一区二区三区在线视频 | 久久久精品视频免费看 | 精品国产一区二区三区性色 | 欧美电影在线 | 日本一区二区三区四区 | 91人人爽| 成人a免费| 久久av一区二区 | www久久爱| 欧美性乱| 精品91av| 亚洲精品白浆高清久久久久久 | 精品久久久久久久久久久院品网 | 91精品国产手机 | 国产精品1区 | 午夜影院在线观看 | 亚洲一区二区三区乱码aⅴ 四虎在线视频 | 911网站大全在线观看 | 一本在线| 男人亚洲天堂 | 欧美久久久久 | 一区二区三区免费 | 天天av网| 亚洲免费视频一区 | 91视频麻豆| 欧美综合一区二区 | 狠狠干天天干 | 欧美日韩亚洲国产 | 毛片免费视频 | 欧美综合久久 | 97超在线视频| h在线播放 | 精品国产一区二区三区久久久蜜月 | 国产91久久久久久 | 国产精品美女在线观看 | 国产乱肥老妇国产一区二 |